The NASA Exoplanet Science Institute (NExScI) provides tools and archives for the exoplanet community, administers the Sagan program of fellowships and workshops, supports the Keck Interferometer and Large Binocular Telescope Interferometer. NExScI provides administration of NASA Keck telescope time, and additional projects in the Exoplanet Exploration Program.

The Spitzer Space Telescope (formerly SIRTF), the infrared component of NASA's series of Great Observatories, was launched on August 25, 2003. The Spitzer Science Center is located within IPAC, and the Spitzer Heritage Archive is hosted by IRSA.

Proposed for launch in 2017 as part of NASA's Explorers Program, FINESSE would take the first "family portrait" of extrasolar planets, or exoplanets. FINESSE is the first mission dedicated to finding out what exoplanet atmospheres are made of, what conditions or processes are responsible for their composition, and how our own solar system fits into the larger family of planets.

The Near-Earth Object Camera (NEOCam) is a new mission proposal designed to discover and characterize most of the potentially hazardous asteroids that are near the Earth. NEOCam consists of an infrared telescope and a wide-field camera operating at thermal infrared wavelengths. The NEOCam proposal has recently been funded by NASA for technology development.