The Spitzer Space Telescope (formerly SIRTF), the infrared component of NASA's series of Great Observatories, was launched on August 25, 2003. The Spitzer Science Center is located within IPAC, and the Spitzer Heritage Archive is hosted by IRSA.

The NASA Exoplanet Science Institute (NExScI) provides tools and archives for the exoplanet community, administers the Sagan program of fellowships and workshops, supports the Keck Interferometer and Large Binocular Telescope Interferometer. NExScI provides administration of NASA Keck telescope time, and additional projects in the Exoplanet Exploration Program.

HIRES employs the Maximum Correlation Method (MCM) (H.H. Aumann, J.W. Fowler and M. Melnyk, 1990,AJ, 99,1674) to construct (resolution-enhanced) coadded images. HIRES images may be requested from IPAC using the e-mail based data request system.

IRSKY offers convenient and efficient access to the major released science products from the IRAS (Infrared Astronomical Satellite) mission. It is designed as an environment for astronomers to plan observations in the context of the known infrared sky, with special emphasis on observations using Spitzer.

The Infrared Space Observatory (ISO) was launched by ESA in late 1995 and operated for 30 months before the cryogen was exhausted. IPAC's role included improving data pipelines and specialized software analysis tools to yield the best quality calibration and data reduction methods from the mission. IPAC also supported ISO observers and data archive users through in-house visits and workshops, and developed IRSA's ISO visualizer.

The Midcourse Space Experiment (MSX), a BMDO-sponsored military satellite, was launched in April 1996. Collaborative efforts between the Air Force Research Laboratory and IPAC has resulted in an archive containing images for about 15 percent of the sky, including the entire Galactic Plane, the Large Magellanic Cloud, and regions of the sky missed by IRAS. The MSX data archive is hosted by IRSA at IPAC.

Skyview is an image display and analysis program for the interactive analysis of astronomical data using the X-Windows user interface. Skyview is primarily intended for the analysis of flux/intensity and position calibrated scientific imagery.

The Wide-field Infrared Explorer (WIRE) was a NASA Small Explorer mission. IPAC provided science operations and data analysis for WIRE.

IBIS is an electronic mail, batch version of IRSKY, the tool primarily intended for planning infrared observations.

For ten months in 1983, the Infrared Astronomical Satellite (IRAS) scanned more than 96 percent of the sky. IRAS was a joint project of the US, UK and the Netherlands. The IRAS mission performed an unbiased, sensitive all sky survey at 12, 25, 60 and 100 µm. IPAC was founded to support IRAS, and currently the IRAS archive of catalogs, images tools and documentation is held in the IRSA archive at IPAC.

The Infrared Telescope in Space (IRTS) is a cryogenically cooled, small infrared telescope that flew from March - April in 1995. It surveyed approximately 10% of the sky with a relatively wide beam during its 20 day mission.

The Palomar Testbed Interferometer (PTI) was a near-infrared stellar interferometer located at Palomar Observatory and operated by JPL. PTI operated as a science facility by the NASA Exoplanet Science Institute (NExScI) at IPAC.

The Two Micron All-Sky Survey (2MASS) is a near-infrared digital imaging survey of the entire sky conducted by the University of Massachusetts and IPAC at 1.25, 1.65 and 2.17 microns. IPAC was responsible for all data processing through the Production Pipeline, and construction and distribution of the data products.