The Spitzer Space Telescope (formerly SIRTF), the infrared component of NASA's series of Great Observatories, was launched on August 25, 2003. The Spitzer Science Center is located within IPAC, and the Spitzer Heritage Archive is hosted by IRSA.

The Wide-field Infrared Survey Explorer (WISE) provides an all-sky survey from 3 to 25 microns which is up to 500 times more sensitive than the previous infrared all-sky survey from IRAS survey. WISE launched on 14 December 2009. The Infrared Processing and Analysis Center (IPAC) is responsible for data processing and archiving, and preparing images for public release into the image gallery.

The Wide-Field Infrared Survey Telescope (WFIRST) is the top-ranked large space mission from the Astro2010 Decadal Survey. NASA is conducting a formulation phase study of a design reference mission that would be capable of addressing essential questions in the areas of exoplanets, dark energy, and infrared astrophysics.